Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease. It occurs when the heart muscle doesn't get as much blood as it needs.
Angina usually causes uncomfortable pressure, fullness, squeezing or pain in the center of the chest.¹

A stroke occurs when something blocks blood supply to part of the brain or when a blood vessel in the brain bursts. In either case, parts of the brain become damaged or die. A stroke can cause lasting brain damage, long-term disability, or even death. There are two types of stroke:

• An ischemic stroke occurs when blood clots or other particles block the blood vessels to the brain. Fatty deposits called plaque can also cause blockages by building up in the blood vessels.
• A hemorrhagic stroke occurs when a blood vessel bursts in the brain. Blood builds up and damages surrounding brain tissue.

ED is a condition in which the patient is unable to get or keep an erection firm enough for satisfactory sexual intercourse. ED is often a symptom of another health problem or health-related factor.
Many different factors affecting  vascular system, nervous system and endocrine system can cause or contribute to ED.¹

Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose.
It is used for the treatment of type 2 diabetes in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glucose control.
The usual starting dose is one tablet 2 or 3 times daily given during or after meals. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. The maximum recommended dose is 3 g daily.
Metformin is available in the EU under the following trade names (as a monotherapy): Dianben, Glucophage and Risidon

Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea class. It appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets.
It is used for the treatment of type 2 diabetes in adults.
The recommended starting dose is 5 mg, given before breakfast. Dosage adjustments should ordinarily be in increments of 2.5–5 mg, as determined by blood glucose response. At least several days should elapse between titration steps. The maximum recommended once daily dose is 15 mg. If response to a single dose is not satisfactory, dividing that dose may prove effective. The maximum recommended total daily dose is 40 mg.

BMI is a person’s weight in kilograms divided by the square of height in meters.¹

A high BMI can indicate high body fatness.